ironjustice
2020-10-23 18:02:38 UTC
LEUKOCYTE TELOMERE LENGTH IS ASSOCIATED WITH IRON OVERLOAD IN MALE ADULTS WITH HEREDITARY HEMOCHROMATOSIS
Biosci Rep
2020 Oct 7;BSR20201916. doi: 10.1042/BSR20201916.
Maximiliano Martin 1, Andrea Millan 2, Florencia Ferraro 1, Walter Francisco Tetzlaff 3, Ezequiel Lozano Chiappe 1, Eliana Botta 1, Marcelo Castro 4, Laura Boero 1, Jorge Rey 4, Jorge Daruich 4, Gustavo Frechtel 2, Tomas Merono 3, Gloria Cerrone 2, Fernando Brites 1
PMID: 33026063 DOI: 10.1042/BSR20201916
Free article
Abstract
Hereditary hemochromatosis (HH) is a primary iron overload (IO) condition. Absolute telomere length (ATL) is a marker of cellular aging and DNA damage associated with chronic diseases and mortality.
Aim: To evaluate the relationship between ATL and IO in patients with HH.
Methods: Cross-sectional study including25 patients with HH: 8 with IO and 17 without IO (ferritin< 300ng/ml) and 25 healthy controls.
Inclusion criteria were: age>18 years, male sex and HH diagnosis. Patients with diabetes or other endocrine and autoimmune diseases were excluded. ATL was measured by real-time PCR.
Results: HH patients with IO were older (p<0.001) and showed higher ferritin concentration (p<0.001). Patients with HH, disregarding the iron status, showed higher glucose and BMI than controls (both p<0.01). ATL was shorter in patients with IO than controls [with IO: 8 (6-14), without IO: 13 (9-20),and controls: 19 (15-25) kilobase pairs, p<0.01];with a linear trend within groups (p for trend<0.01). Differences in ATL remained statistically significant after adjusting by age, BMI and glucose(p<0.05).
Discussion: Patients with IO featured shorter ATL while patients without IO showed only mild alterations vs. controls. Screening for IO is encouraged to prevent iron-associated cellular damage and early telomere attrition.
Keywords: Iron Metabolism; Iron Overload; Telomere Lenght.
Copyright 2020 The Author(s).
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Biosci Rep
2020 Oct 7;BSR20201916. doi: 10.1042/BSR20201916.
Maximiliano Martin 1, Andrea Millan 2, Florencia Ferraro 1, Walter Francisco Tetzlaff 3, Ezequiel Lozano Chiappe 1, Eliana Botta 1, Marcelo Castro 4, Laura Boero 1, Jorge Rey 4, Jorge Daruich 4, Gustavo Frechtel 2, Tomas Merono 3, Gloria Cerrone 2, Fernando Brites 1
PMID: 33026063 DOI: 10.1042/BSR20201916
Free article
Abstract
Hereditary hemochromatosis (HH) is a primary iron overload (IO) condition. Absolute telomere length (ATL) is a marker of cellular aging and DNA damage associated with chronic diseases and mortality.
Aim: To evaluate the relationship between ATL and IO in patients with HH.
Methods: Cross-sectional study including25 patients with HH: 8 with IO and 17 without IO (ferritin< 300ng/ml) and 25 healthy controls.
Inclusion criteria were: age>18 years, male sex and HH diagnosis. Patients with diabetes or other endocrine and autoimmune diseases were excluded. ATL was measured by real-time PCR.
Results: HH patients with IO were older (p<0.001) and showed higher ferritin concentration (p<0.001). Patients with HH, disregarding the iron status, showed higher glucose and BMI than controls (both p<0.01). ATL was shorter in patients with IO than controls [with IO: 8 (6-14), without IO: 13 (9-20),and controls: 19 (15-25) kilobase pairs, p<0.01];with a linear trend within groups (p for trend<0.01). Differences in ATL remained statistically significant after adjusting by age, BMI and glucose(p<0.05).
Discussion: Patients with IO featured shorter ATL while patients without IO showed only mild alterations vs. controls. Screening for IO is encouraged to prevent iron-associated cellular damage and early telomere attrition.
Keywords: Iron Metabolism; Iron Overload; Telomere Lenght.
Copyright 2020 The Author(s).
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk