2017-04-27 06:38:43 UTC
Full paper is not behind a paywall.
1. Nutrients. 2017 Mar 16;9(3). pii: E290. doi: 10.3390/nu9030290.
Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement.
Butawan M(1), Benjamin RL(2), Bloomer RJ(3).
Methylsulfonylmethane (MSM) has become a popular dietary supplement used for a
variety of purposes, including its most common use as an anti-inflammatory agent.
It has been well-investigated in animal models, as well as in human clinical
trials and experiments. A variety of health-specific outcome measures are
improved with MSM supplementation, including inflammation, joint/muscle pain,
oxidative stress, and antioxidant capacity. Initial evidence is available
regarding the dose of MSM needed to provide benefit, although additional work is
underway to determine the precise dose and time course of treatment needed to
provide optimal benefits. As a Generally Recognized As Safe (GRAS) approved
substance, MSM is well-tolerated by most individuals at dosages of up to four
grams daily, with few known and mild side effects. This review provides an
overview of MSM, with details regarding its common uses and applications as a
dietary supplement, as well as its safety for consumption.