Post by Taka Post by Rejected Man
Low-fat dairy but not high-fat dairy is associated with Parkinson's disease.
Any proposed mechanisms?
On the face of it, this suggests the fat is protective.
They always grab the money and say "more research is needed"..... In some low fat milk products they remove the saturated fat completely and put back some amount of an Omega-6 rich vegetable oil or the "healthy" Omega-3 fats! Skimmed milk is highly oxidized including the oxysterols. And then yo get the devil's sugar galactose in it (a part of lactose)...
Now that I think about it, skim milk often contains a percentage of milk that has been dehydrated here in the States. Oxysterols could certainly place role.
Free Radic Biol Med. 2016 Dec;101:393-400. doi:
10.1016/j.freeradbiomed.2016.10.008. Epub 2016 Nov 9.
Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson's
Doria M(1), Maugest L(2), Moreau T(2), Lizard G(1), Vejux A(3).
Neurodegenerative diseases are a major public health issue worldwide. Some
countries, including France, have engaged in research into the causes of
Parkinson's disease, Alzheimer's disease, and multiple sclerosis and the
management of these patients. It should lead to a better understanding of the
mechanisms leading to these diseases including the possible involvement of lipids
in their pathogenesis. Parkinson's disease is a progressive neurodegenerative
disorder characterized by the loss of dopaminergic neurons in the substantia
nigra and the accumulation of α-synuclein (Lewy bodies). Several in vivo studies
have shown a relationship between the lipid profile [cholesterol, oxidized
cholesterol products (oxysterols) formed either enzymatically or by
auto-oxidation], the use of drugs regulating cholesterol levels, and the
development of Parkinson's disease. Several oxysterols are present in the brain
and could play a role in the development of this disease, particularly in the
accumulation of α-synuclein, and through various side effects, such as oxidation,
inflammation, and cell death. Consequently, in Parkinson's disease, some
oxysterols could contribute to the pathophysiology of the disease and constitute
potential biomarkers or therapeutic targets.