Discussion:
Source for Dinh lang extract found
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r***@yahoo.com
2007-12-04 21:32:13 UTC
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Someone on another forum found a source for the extract Dinh Lang
(policias fruticosum), as part of an herbal complex. This herbal
extract has significantly extended maximum lifespan in rodent studies,
and synergizes with deprenyl in extending maximum lifespan.

http://www.gvi.com/Scripts/prodView.asp?idproduct=39
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http://www.quantium.plus.com/lr/lr57.htm#D...ends%20Lifespan

1: Acta Physiol Hung. 1992;79(2):119-24. Related Articles, Links

Extension of lifespan in mice treated with Dinh lang (Policias
fruticosum L.) and (-)deprenyl.

Yen TT, Knoll J.

Department of Pharmacology, Semmelweis University Medical School,
Budapest, Hungary.

The effect of Dinh lang root extract (DLRE) and (-)deprenyl on memory
function and lifespan was examined in OFA-1 male mice. Treatments of
either DLRE, (-)deprenyl or their combination were carried out 3
times
a week starting at 12 months of age and following to the end of life.
DLRE and (-)deprenyl significantly increased the memory function as
well as surviving time of aged mice. The drug-treated animals showed
a
lower rate of loss of body weight than saline treated ones. It
suggested that DLRE and (-)deprenyl did not prolong lifespan of mice
by suppressing food intake. The combined treatment of DLRE and
(-)deprenyl proved to be the most effective.

PMID: 1304677 [PubMed - indexed for MEDLINE]

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2: Acta Physiol Hung. 1990;75(1):69-76. Related Articles, Links

Improvement of learning ability in mice and rats with the root
extract
of dinh lang (Policias fruticosum L.).

Tran Ty Yen.

Department of Pharmacology, Semmelweis University Medical School,
Budapest, Hungary.

The effect of Dinh lang root extract (DLRE) on the learning ability
of
mice and rats was studied. The learning performance in groups of rats
belonging to different age-cohorts (4-6 months, 16-18 months and
22-24
months) was studied in the shuttle-box and the age-related decline in
the acquisition of a conditioned avoidance response (CAR) was
established. Using the passive avoidance test also in mice, an age-
related decay in performance, was detected. DLRE treatment 10 mg/kg
daily for 3-4 weeks restored the lost ability of 22-24 months old
rats
to develop CAR, the same treatment significantly improved the
performance of young mice and improved retention in both 5-months old
and 19-20 months old groups of mice.


PMID: 2339609 [PubMed - indexed for MEDLINE]

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3: Acta Physiol Hung. 1990;75(1):61-7. Related Articles, Links

Stimulation of sexual performance in male rats with the root extract
of dinh lang (Policias fruticosum L.).

Tran Ty Yen.

Department of Pharmacology, Semmelweis University Medical School,
Budapest, Hungary.

Ginseng (Panax ginseng C.A. Meyer) is probably the best known
medicinal plant, the extract of which is used in the Far East as a
traditional remedy. Dinh lang (Polycias fruticosum L.) root extract
(DLRE) was found to have a pharmacological spectrum similar to
Ginseng. Experimental and clinical studies have shown a wide range of
pronounced stimulatory effects of DLRE which showed low toxicity. It
increases mental and physical performance. This study is devoted to
demonstrate the effect of DLRE on sexual performance of male rats.
Different age-cohorts of Wistar male rats [6-8 months old (n = 204),
16-18-months old (n = 240) and 22-24 month old (n = 122)], were used
for these experiments. The rats of each age cohort were divided into
4
groups. One group received saline, others were treated with various
doses of DLRE daily. Treatment started 10 days before the screening
test and continued during the test period. DLRE reduced the
percentage
of non-copulators in the aged rats compared to the younger ones. In
the aged rats DLRE transformed high percentage of sluggish rats to
sexually fully active animals. In sexually fully active 6-8 months
old
rats the percentage of rats displaying ejaculation with the second
female was found to be significantly higher in DLRE-treated males.
Also the recovery of the sexually exhausted male rats proved to be
faster in DLRE-treated groups.

PMID: 2339608 [PubMed - indexed for MEDLINE]

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4: Acta Physiol Hung. 1990;75 Suppl:301-2. Related Articles, Links

The effect of dinh lang and (-)deprenyl on the survival rate of male
rats.

Yen TT, Dallo J, Knoll J.

Department of Pharmacology, Semmelweis University of Medicine,
Budapest, Hungary.

PMID: 2115236 [PubMed - indexed for MEDLINE]
r***@yahoo.com
2007-12-04 23:39:29 UTC
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From:
http://www.quantium.plus.com/lr/lr57.htm#Dinh%20Lang%20Extends%20Lifespan

Dinh Lang Extends Lifespan

Alcoholic extracts from the Vietnamese herb dinh lang has been proven
to be effective in extending rodent maximum lifespan.

Here's some data.

Dinh lang extract and deprenyl have some additive effects on
prolonging the lifespan of OFA-1 mice. (Acta Physiologica Hungarica
79(2): 119-124 1992)

Group Maximum Lifespan

control 133 weeks

dinh lang 170

deprenyl 162

both 180

This also works in Wistar rats as well. (Acta Physiologica Hungarica
75: 301-302 1990)

Group Average Maximum

Lifespan Lifespan

control 147 164 weeks

dinh lang 180 194

dinh lang & 206 239

deprenyl

The life extending effect of dinh lang extract appears to be quite
real as it has been demonstrated in two strains of rodents. Moreover
dinh lang appears to be more effective than deprenyl.

n addition the dosage used was probably suboptimal. Only 10 mg/kg
extract was used in the life extension experiments, while maximal
effects of passive avoidance performance in young OFA mice was found
at 20 mg/kg. (Acta Physiologica Hungarica 75(1): 69-76 1990) In Wistar
rats aged 22-24 months 20.8% resumed full scale sexual activity at a
dosage of 20 mg/kg, 11.5% at 10 mg/kg, 7.7% at 5 mg/kg and 0% for
controls. (Acta Physiologica Hungarica 75(1): 61-67 1990)
Curious
2007-12-06 21:05:34 UTC
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However the only papers are from the same team, never reproduced.

regards
Curious
Paul Antonik Wakfer
2007-12-07 03:03:10 UTC
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Post by Curious
However the only papers are from the same team, never reproduced.
regards
Curious
Scientifically that is important, ie with respect to issues relating
to "proof". But with the current mode of operation of the scientific
establishment, there is little likelihood of any such reproduction of
such studies. Unless there is come clear reason for doubting the
results, I therefore think that any serious life extensionist needs to
be aware of all such studies and independently appraise the potential
benefits versus the costs and potential negativities related to all
such studied modalities.

--Paul Wakfer

MoreLife for the rational - http://morelife.org
Reality based tools for more life in quantity and quality
The Self-Sovereign Individual Project - http://selfsip.org
Self-sovereignty, rational pursuit of optimal lifetime happiness,
individual responsibility, social preferencing & social contracting
Paul Antonik Wakfer
2007-12-04 23:58:33 UTC
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Post by r***@yahoo.com
Someone on another forum found a source for the extract Dinh Lang
(policias fruticosum), as part of an herbal complex. This herbal
extract has significantly extended maximum lifespan in rodent studies,
and synergizes with deprenyl in extending maximum lifespan.
Loading Image... (label information)
http://www.quantium.plus.com/lr/lr57.htm#D...ends%20Lifespan
[snipped abstracts]

Thanks for the information.
Dinh lang is also mentioned in the full text of the following more
recent review paper (see the abbreviations list on the Science Direct
abstract): http://pmid.us/11295356

--Paul Wakfer

MoreLife for the rational - http://morelife.org
Reality based tools for more life in quantity and quality
The Self-Sovereign Individual Project - http://selfsip.org
Self-sovereignty, rational pursuit of optimal lifetime happiness,
individual responsibility, social preferencing & social contracting
c***@my-deja.com
2007-12-13 20:21:20 UTC
Permalink
It only took, what...5 or 10 years for someone to finally bottle DL
here. I had a few trees that I tried to grow indoors - unsuccessfully.
I was never certain if they came from a chem/pesticide free nursery
anyway.

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